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                                                          4月3日學術報告信息

                                                          發佈時間:2019-04-01來源:网易彩票點擊數:10

                                                          報告題目:精準記憶的環路機制

                                                          報 告 人:魯友明教授

                                                              華中科技大學同濟醫學院

                                                          報告時間43日上午10:00

                                                          報告地點:网易彩票E307學術報告廳

                                                          邀 請 人:韓家淮教授  莫瑋教授

                                                          聯 系 人:彭永瑩2181601


                                                          報告摘要

                                                          Mossy cells (MCs) are a unique group of excitatory neurons in the dentate gyrus, which is a brain region important for emotion, learning and memory. Due to the lack of a reliable method to identify and distinguish MCs from the other cell types, a specific function and circuit of MCs remains unknown. Here, we genetically label the individual MCs in the dentate gyrus of adult mice and demonstrate that MCs control memory precision. MCs synapse directly with local somatostatin (SST)-expressing interneurons and undergo long-term potentiation (LTP) that requires activation of postsynaptic GluR2-lacking, Ca2+-permeable AMPA receptor. GluR2 expression in SST cells is repressed by a long non-coding RNA, PRECISER. A genetic switch of synaptic AMPA receptor phenotype from GluR2-lacking, Ca2+-permeable to GluR2-containing, Ca2+-impermeable AMPA receptor by either directly introducing GluR2 or silencing PRECISER in SST cells blocks LTP and causes memory imprecision. Thus, MCs directly and functionally innervate local SST cells and this innervation governs memory precision via GluR2-lacking, Ca2+-permeable AMPA receptor-mediated LTP.